Best Formula Milk for Newborn Babies in USA 2022

If you are looking for the best formula milk for baby who is from 0-6 months old in USA, you've come to the right place. Breastmilk is nature's perfect baby food. But if you can’t breastfeed, or if you’ve chosen not to, formula milk is the next best thing. Scientists and medical experts have spent years developing high-quality formula milks that will provide your baby with the nutrition she needs

When you’re deciding which is the best milk powder for your baby, you will need to take several factors into consideration. Think about her health and dietary needs, her age, and the cost and preparation time of different formula milks. 

As a summary, there are three different types of formula:
  • cow’s milk-based formula
  • hydrolysed protein formula
  • soya-based formula
It’s most likely your baby can have cow’s milk-based formula, unless there’s a health or dietary reason why she can’t. 

Update: Many of the infant formula products are out of stock on Amazon. You may wish to keep your options open to multiple online and offline channels or visit the site regularly to check whether the items are back in stock.

Best Infant Formula USA 2020 / 2021

There are many different brands for baby or infant milk formulas in USA. We have trawled through the reviews, Google search results and milk powder comparison information available on blogs and forums, and shortlisted the best for you. Here are the best baby milk powders you can buy online in USA today.

Best Formula Milk for Baby 0-6 Months (Summary)


1. Similac Pro-Advance Non-GMO Infant Formula with Iron

This Similac baby milk formula has more than 3,900 customer reviews and is the no. 1 best seller in the powder baby formula category of Amazon Best Sellers. Similac has one of the widest range of milk powders in USA.

The Best Sellers in Baby and Toddler Formula category of Amazon Best Sellers are updated hourly based on sales.



Similac Pro-Advance Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support, Baby Formula, Powder, (One-Month Supply), 2.25 Pound (Pack of 3) > Check Price on Amazon

Similac Pro-Advance is their closest formula to breast milk. This baby milk formula is a well-formulated baby formula with 2’-FL human milk oligosaccharide that provides immune support to the baby by encouraging immune cells to release protective proteins in amounts more like the breastfed baby.

This baby Milk formula for 0-6 Months baby is also one of the leading infant formula with no artificial growth hormones.

More about the baby milk formula
  • 2'FL HMO (Human Milk Oligosaccharide) adds another layer to Similac’s already proven immune support
  • DHA, Lutein, and Vitamin E for Brain & Eye Development
  • Highly recommended by mothers
  • No Artificial Growth Hormones
  • Backed by more than 15 years of extensive research

2. Enfamil NeuroPro Gentlease Baby Formula

The Enfamil NeuroPro babay formula has more than 2,500 customer reviews and is the no. 2 best seller in the powder baby formula category of Amazon Best Sellers.


Enfamil NeuroPro Gentlease Baby Formula Milk Powder, 19.5 Ounce > Check Price on Amazon

More about the baby milk formula
  • Emerging evidence from a recent clinical study showed MFGM in formula supports cognitive development similar to breast milk
  • #1 trusted brand for brain-building & immune support
  • Get brain building nutrition inspired by breast milk from the formula brand that's #1 recommended by Pediatricians
  • For easing fussiness, gas and crying within 24 hours
  • The only formula that has a fat-protein blend of MFGM and DHA, previously only found in breast milk
  • Complete nutrition for babies through 12 months, easy-to-digest proteins and dual prebiotics for immune health

my little guy really took to this formula i was really worried because others i have tried have left him fussy and gassy with a nasty habit of spitting up on everything and everyone. this time no such issues i am guessing that it is due to it being so similar to breast milk so my little guy who gets formula as a supplement was better able to handle it. this was also super easy to mix up with no nasty clumps left either in the nipple or in the bottom of the bottle


3. Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support

This Similac baby milk formula has more than 4,600 customer reviews and is the no. 3 best seller in the powder baby formula category of Amazon Best Sellers. 

Similac Pro-Advance Infant Formula with 2'-FL Human Milk Oligosaccharide (HMO) for Immune Support, 23.2 ounces > Check Price on Amazon

More about the baby milk formula
  • #1 BRAND FOR IMMUNE SUPPORT*: Similac Pro-Advance is the first infant formula with 2’- FL HMO** designed to be closer than over to breast milk. (*IQVIA ProVoice Survey 12 months ending February 2020; **not from human milk)
  • NO ARTIFICIAL GROWTH HORMONES: Similac is the first leading infant formula brand with no artificial growth hormones (No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows)
  • REDUCED FUSSINESS: Parents reported reduced fussiness, gassiness, and spit-up after 1 day (After switching to Similac Pro-Advance)
  • TRUSTED: Similac is the #1 infant formula brand chosen by moms* and the #1 brand fed in hospitals (*total US infant formula all outlets as of 3/31/18, Nielsen data)
  • BRAIN & EYE DEVELOPMENT: Our exclusive blend of DHA, Lutein, and Vitamin E – nutrients also found in breast milk – helps support baby’s overall growth and brain and eye development


4. Similac Pro-Sensitive Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support

Another Similac baby milk formula best seller with more than 2,200 customer reviews and is currently the no. 4 best seller in the powder baby formula category of Amazon Best Sellers. 



Similac Pro-Sensitive Non-GMO Infant Formula with Iron, with 2’-FL HMO, for Immune Support, Baby Formula, Powder, 2.18 Lb (Pack of 3) (One-Month Supply) > Check Price on Amazon

Description about the baby milk formula
  • Similac Pro-Sensitive is the first infant formula for sensitive tummies with 2’-FL HMO;(Based on Pediatrician Recommendations and IQVIA ProVoice Survey 12 months ending February 2020; not from human milk)
  • VALUE SIZE/SUBSCRIBE and SAVE: 1 Can provides 55% more powder than the 1.41-lb container; 3 cans provide a one-month supply or 189 4-fl-oz bottles; Choose Subscribe and Save for additional savings and convenience
  • FOR SENSITIVE TUMMIES: Designed for fussiness and gas due to lactose sensitivity; Not for infants or children with galactosemia
  • IMMUNE SUPPORT: Similac Pro-Sensitive is the first infant formula with 2’-FL human milk oligosaccharide (Not from human milk)
  • TRUSTED: Similac is the No.1 infant formula brand chosen by moms and the No.1 brand fed in hospitals (total US infant formula all outlets as of 3/31/18, Nielsen data)
  • OptiGRO: Our exclusive blend of DHA, Lutein, and Vitamin E, nutrients also found in breast milk, help support baby’s brain and eye development
  • Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
  • In select stores; The SNAP (Supplemental Nutrition Assurance Program) name is a service mark of the U.S. Department of Agriculture;USDA does not endorse any goods, services, or enterprises       

5. Earth's Best Organic Dairy Infant Powder Formula with Iron, Omega-3 DHA and Omega-6 ARA

This organic baby milk formula has more than 2,800 customer reviews and is the no. 6 best seller in the powder baby formula category of Amazon Best Sellers. 


Earth's Best Organic Dairy Infant Powder Formula with Iron, Omega-3 DHA and Omega-6 ARA, 23.2 oz > Check Price on Amazon

Description about the baby milk formula
  • Organic formula that is easy to digest and nutritionally complete for baby's first twelve months
  • All lactose milk based powder formulation; our closest formula to breast milk, no added corn syrup solids
  • Omega 3 DHA and Omega 6 ARA fatty acids naturally found in breast milk to support brain and eye development, Iron for healthy development
  • With Lutein for Eyes and Prebiotic Fructo-oligosaccharides for Immunity
  • Non-GMO ingredients and Kosher; Made without prohibited synthetic pesticides and fertilizers. No artificial growth hormones

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